BDBM50319611 (R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-2-(trifluoromethyl)-benzonitrile::CHEMBL1085593

SMILES CC1(C)CN(Cc2ccccc2)C(=O)[C@@H]1Oc1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=SGVUYXVVBNOJLA-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50319611   

TargetGlucocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to estrogen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 4.40E+3nMAssay Description:Binding affinity to progesterone receptor by PRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 100nMAssay Description:Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human androgen receptor by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 30nMAssay Description:Binding affinity to human androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human androgen receptor by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 30nMAssay Description:Binding affinity to human androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 100nMAssay Description:Binding affinity to human Androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at Androgen receptor in human MDA-kb2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed