BDBM50319574 CHEMBL1086334::N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-3H-imidazo[4,5-c]pyridin-2-amine

SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccncc3[nH]2)c2ccccc12

InChI Key InChIKey=QHQWGJPISLNJMT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50319574   

TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319574(N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 454nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319574(N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319574(N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 6.36E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319574(N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319574(N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50: 86nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed