BDBM50319570 1-ethyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)urea::CHEMBL1084634

SMILES CCNC(=O)Nc1ccc(Oc2ncccc2-c2ccnc(NC)n2)c2ccccc12

InChI Key InChIKey=RETUSTLIJKZUGV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50319570   

TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319570(1-ethyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyr...)
Affinity DataIC50: 130nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319570(1-ethyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyr...)
Affinity DataIC50: 534nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319570(1-ethyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyr...)
Affinity DataIC50: 48nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319570(1-ethyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyr...)
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319570(1-ethyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyr...)
Affinity DataIC50: 248nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed