BDBM50319569 1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)urea::CHEMBL1084633

SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)NC(C)(C)C)c2ccccc12

InChI Key InChIKey=OKKAENUKIYEBBD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50319569   

TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319569(1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-y...)
Affinity DataIC50: 55nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319569(1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-y...)
Affinity DataIC50: 225nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319569(1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-y...)
Affinity DataIC50: 2.22E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319569(1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-y...)
Affinity DataIC50: 4.09E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319569(1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-y...)
Affinity DataIC50: 215nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed