BDBM50319285 5-fluoro-4-methyl-2-(2-methyl-4-(3-((4aR,7aR)-tetrahydro-1H-pyrrolo[3,4-b]pyridin-6(2H,7H,7aH)-yl)propoxy)phenyl)-1H-benzo[d]imidazole::CHEMBL1082296

SMILES Cc1cc(OCCCN2C[C@H]3CCCN[C@H]3C2)ccc1-c1nc2ccc(F)c(C)c2[nH]1

InChI Key InChIKey=VORZMLWIEYTBEN-UHFFFAOYSA-N

Data  1 KI  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50319285   

TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50319285(5-fluoro-4-methyl-2-(2-methyl-4-(3-((4aR,7aR)-tetr...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forsko...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50319285(5-fluoro-4-methyl-2-(2-methyl-4-(3-((4aR,7aR)-tetr...)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in human SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50319285(5-fluoro-4-methyl-2-(2-methyl-4-(3-((4aR,7aR)-tetr...)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [125I]APT from human recombinant histamine H2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50319285(5-fluoro-4-methyl-2-(2-methyl-4-(3-((4aR,7aR)-tetr...)
Affinity DataEC50:  119nMAssay Description:Displacement of [125H]iodoproxyphan from human recombinant histamine H3 receptor expressed in human SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Mouse)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50319285(5-fluoro-4-methyl-2-(2-methyl-4-(3-((4aR,7aR)-tetr...)
Affinity DataEC50:  1.20E+3nMAssay Description:Displacement of [3H]histamine from mouse recombinant histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50319285(5-fluoro-4-methyl-2-(2-methyl-4-(3-((4aR,7aR)-tetr...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed