BDBM50318298 (+)-(R)-3-tert-butyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate::CHEMBL1099083

SMILES COC(=O)C1[C@H](C(C(=O)OC(C)(C)C)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O

InChI Key InChIKey=BBKNEXLBDUPYET-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50318298   

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318298((+)-(R)-3-tert-butyl 5-methyl 2,6-dimethyl-4-(3-ni...)
Affinity DataIC50: 46nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318298((+)-(R)-3-tert-butyl 5-methyl 2,6-dimethyl-4-(3-ni...)
Affinity DataIC50: 126nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318298((+)-(R)-3-tert-butyl 5-methyl 2,6-dimethyl-4-(3-ni...)
Affinity DataIC50: 768nMAssay Description:Inhibition of progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318298((+)-(R)-3-tert-butyl 5-methyl 2,6-dimethyl-4-(3-ni...)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318298((+)-(R)-3-tert-butyl 5-methyl 2,6-dimethyl-4-(3-ni...)
Affinity DataIC50: 3.26E+3nMAssay Description:Inhibition of glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318298((+)-(R)-3-tert-butyl 5-methyl 2,6-dimethyl-4-(3-ni...)
Affinity DataIC50: 126nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed