BDBM50318295 CHEMBL1097751::tert-Butyl (4R)-4-(2-Chloro-4-fluorophenyl)-5-cyano-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate

SMILES CC1=NC(C)=C([C@@H](C1C#N)c1ccc(F)cc1Cl)C(=O)OC(C)(C)C

InChI Key InChIKey=YTFZTDYRARTMPD-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50318295   

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318295(tert-Butyl (4R)-4-(2-Chloro-4-fluorophenyl)-5-cyan...)
Affinity DataIC50: 3.70nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318295(tert-Butyl (4R)-4-(2-Chloro-4-fluorophenyl)-5-cyan...)
Affinity DataIC50: 59nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318295(tert-Butyl (4R)-4-(2-Chloro-4-fluorophenyl)-5-cyan...)
Affinity DataIC50: 246nMAssay Description:Inhibition of androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318295(tert-Butyl (4R)-4-(2-Chloro-4-fluorophenyl)-5-cyan...)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318295(tert-Butyl (4R)-4-(2-Chloro-4-fluorophenyl)-5-cyan...)
Affinity DataIC50: 3.52E+3nMAssay Description:Inhibition of progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318295(tert-Butyl (4R)-4-(2-Chloro-4-fluorophenyl)-5-cyan...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of estrogen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318295(tert-Butyl (4R)-4-(2-Chloro-4-fluorophenyl)-5-cyan...)
Affinity DataIC50: 59nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed