BDBM50317323 CHEMBL1094718::N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide

SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1

InChI Key InChIKey=DVRMYRDLCLUXQP-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50317323   

TargetMacrophage-stimulating protein receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317323(N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno...)
Affinity DataIC50: 50nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317323(N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno...)
Affinity DataIC50: 400nMAssay Description:Inhibition of c-Met-mediated cell migration of human A549 cells by would healingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317323(N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno...)
Affinity DataIC50: 150nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317323(N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of c-Met-mediated scattering in HGF-stimulated human DU145 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317323(N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno...)
Affinity DataIC50: 6.87E+3nMAssay Description:Inhibition of phosphorylation of c-Met in human MKN45 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317323(N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno...)
Affinity DataIC50: 12nMAssay Description:Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317323(N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno...)
Affinity DataIC50: 30nMAssay Description:Inhibition of RON phosphorylation in human PC3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317323(N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno...)
Affinity DataIC50: 30nMAssay Description:Inhibition of RON phosphorylation in human HT29 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317323(N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human RONMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2016
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317323(N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human c-MetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2016
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317323(N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human RONMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317323(N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno...)
Affinity DataIC50: 6.87E+3nMAssay Description:Inhibition of c-Met phosphorylation in human MKN45 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317323(N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno...)
Affinity DataIC50: 500nMAssay Description:Inhibition of c-Met phosphorylation in human MKN45 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317323(N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed