BDBM50316094 3-Ethyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-5-(trifluoromethyl)-quinoxaline::CHEMBL1089232

SMILES CCc1nc2c(cccc2nc1-c1ccc(cc1)-c1cccc(c1)S(C)(=O)=O)C(F)(F)F

InChI Key InChIKey=FHEOPZZFNWUQEY-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50316094   

TargetOxysterols receptor LXR-beta(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316094(3-Ethyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-5-(tr...)
Affinity DataIC50: 18nMAssay Description:Displacement of [3H]T0901317 from human LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316094(3-Ethyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-5-(tr...)
Affinity DataEC50:  3.59E+3nMAssay Description:Agonist activity at human recombinant LXRalpha ligand binding domain in human HuH7 cells co-transfected with fused Gal4-DBD by transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316094(3-Ethyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-5-(tr...)
Affinity DataEC50:  2.02E+3nMAssay Description:Agonist activity at human recombinant LXRbeta ligand binding domain in human HuH7 cells co-transfected with fused Gal4-DBD by transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316094(3-Ethyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-5-(tr...)
Affinity DataIC50: 165nMAssay Description:Displacement of [3H]T0901317 from human LXRalpha ligand binding domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed