BDBM50315204 (R)-2-(6-methoxy-3-(1-(3-methoxypyrazin-2-yl)ethyl)-1H-inden-2-yl)-N,N-dimethylethanamine::CHEMBL1090186

SMILES COc1ccc2C([C@@H](C)c3nccnc3OC)=C(CCN(C)C)Cc2c1

InChI Key InChIKey=AIGMIQVSRPRWAQ-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50315204   

TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315204((R)-2-(6-methoxy-3-(1-(3-methoxypyrazin-2-yl)ethyl...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315204((R)-2-(6-methoxy-3-(1-(3-methoxypyrazin-2-yl)ethyl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315204((R)-2-(6-methoxy-3-(1-(3-methoxypyrazin-2-yl)ethyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315204((R)-2-(6-methoxy-3-(1-(3-methoxypyrazin-2-yl)ethyl...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity at histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315204((R)-2-(6-methoxy-3-(1-(3-methoxypyrazin-2-yl)ethyl...)
Affinity DataKi: >3.00E+3nMAssay Description:Displacement of dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315204((R)-2-(6-methoxy-3-(1-(3-methoxypyrazin-2-yl)ethyl...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity at M1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed