BDBM50315069 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)urea::CHEMBL1091356

SMILES CC(C)N1CCN(CC1)C(=O)c1ccc(NC(=O)Nc2ccc(cc2)-c2nc(nc(n2)N2C3CCC2COC3)C2CCOCC2)cc1

InChI Key InChIKey=QUBPQLLMMSZSGD-UHFFFAOYSA-N

Data  32 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50315069   

LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 148nMAssay Description:Inhibition of PI3Kalpha after 15 to 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2B6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform gamma-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CK1gamma1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ABLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKCbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2A6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDK2/cyclin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of LynAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of RSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315069(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of FynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed