BDBM50314845 3'-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-(E)-5-(2-bromovinyl)-2'-deoxyuridine::CHEMBL1091988

SMILES OC[C@H]1O[C@H](C[C@@H]1n1cc(nn1)-c1ccc(Cl)cc1)n1cc(C=CBr)c(=O)[nH]c1=O

InChI Key InChIKey=MNYPSYJHVXNBMF-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50314845   

TargetThymidine kinase 2, mitochondrial(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50314845(3'-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-be...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant mitochondrial thymidine kinase 2 assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins by scintilla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidine kinase(HHV-1)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50314845(3'-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-be...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of HSV1 thymidine kinase assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDeoxynucleoside kinase(Fruit fly)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50314845(3'-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-be...)
Affinity DataIC50: 460nMAssay Description:Inhibition of Drosophila melanogaster multifunctional deoxynucleoside kinase assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidine kinase, cytosolic(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50314845(3'-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-be...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human recombinant cytosolic thymidine kinase 1 assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins by scintillation...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidine kinase 2, mitochondrial(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50314845(3'-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-be...)
Affinity DataKi:  12nMAssay Description:Competitive inhibition of human recombinant mitochondrial thymidine kinase 2 using ATP as substrate by Lineweaver-Burke plottingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidine kinase 2, mitochondrial(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50314845(3'-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-be...)
Affinity DataKi:  410nMAssay Description:Uncompetitive inhibition of human recombinant mitochondrial thymidine kinase 2 using thymidine as substrate by Lineweaver-Burke plottingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed