BDBM50313328 6-(cyclohexylamino)-N-(4-hydroxy-2-(trifluoromethyl)phenyl)pyrimidine-4-carboxamide::CHEMBL1087651::US9150519, 1-15

SMILES Oc1ccc(NC(=O)c2cc(NC3CCCCC3)ncn2)c(c1)C(F)(F)F

InChI Key InChIKey=TUFUABZMBAGRDK-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50313328   

TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

US Patent
LigandPNGBDBM50313328(6-(cyclohexylamino)-N-(4-hydroxy-2-(trifluoromethy...)
Affinity DataEC50:  380nMpH: 7.4 T: 2°CAssay Description:Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 ug protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

US Patent
LigandPNGBDBM50313328(6-(cyclohexylamino)-N-(4-hydroxy-2-(trifluoromethy...)
Affinity DataEC50: >3.00E+4nMpH: 7.4 T: 2°CAssay Description:Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 ug protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

US Patent
LigandPNGBDBM50313328(6-(cyclohexylamino)-N-(4-hydroxy-2-(trifluoromethy...)
Affinity DataEC50:  382nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed