BDBM50313321 6-(cyclohexyl(methyl)amino)-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide::CHEMBL1081271::US9150519, 1-21

SMILES CN(C1CCCCC1)c1cc(ncn1)C(=O)Nc1ccc(O)cc1C

InChI Key InChIKey=FNJQXCOVHUVDTB-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50313321   

TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

US Patent
LigandPNGBDBM50313321(6-(cyclohexyl(methyl)amino)-N-(4-hydroxy-2-methylp...)
Affinity DataEC50:  660nMpH: 7.4 T: 2°CAssay Description:Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 ug protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2016
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

US Patent
LigandPNGBDBM50313321(6-(cyclohexyl(methyl)amino)-N-(4-hydroxy-2-methylp...)
Affinity DataEC50:  655nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed