BDBM50311985 3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol::CHEMBL1087650

SMILES CN1C[C@@H]2C[C@H]1CN2c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc(O)c1

InChI Key InChIKey=MZPDPRITYJNRSG-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50311985   

TargetTyrosine-protein kinase HCK(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 69nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 675nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 9.71E+3nMAssay Description:Inhibition of RSk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 119nMAssay Description:Inhibition of PKCbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 6.56E+3nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of MetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of LYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 2.46E+3nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of GCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 1.94E+3nMAssay Description:Inhibition of FYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform gamma-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 9.51E+3nMAssay Description:Inhibition of CK1gamma1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 2.64E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 563nMAssay Description:Inhibition of ABL1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 1.86E+4nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 2.84E+4nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 2.55E+4nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IKKalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed