BDBM50308960 2-(4-((9H-xanthene-9-carbonyl)carbamothioyl)piperazin-1-yl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid::2-(4-(9H-xanthene-9-carbonylcarbamothioyl)piperazin-1-yl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid::CHEMBL406020

SMILES CCn1cc(C(O)=O)c(=O)c2cnc(nc12)N1CCN(CC1)C(=S)NC(=O)C1c2ccccc2Oc2ccccc12

InChI Key InChIKey=MXISJWFXBBXOJB-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50308960   

TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50308960(2-(4-(9H-xanthene-9-carbonylcarbamothioyl)piperazi...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of autotaxin-mediated FS3 hydrolysis in human MDA-MB-435 cells by amplex red protocolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50308960(2-(4-(9H-xanthene-9-carbonylcarbamothioyl)piperazi...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of autotaxin-mediated pNP-TMP hydrolysis in human MDA-MB-435 cells by amplex red protocolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50308960(2-(4-(9H-xanthene-9-carbonylcarbamothioyl)piperazi...)
Affinity DataKi:  2.70E+3nMAssay Description:Mixed-type inhibition of autotaxin-mediated FS3 hydrolysis by Michaelis-Menten analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50308960(2-(4-(9H-xanthene-9-carbonylcarbamothioyl)piperazi...)
Affinity DataKi:  2.70E+3nMAssay Description:Competitive-type inhibition of autotaxin-mediated pNP-TMP hydrolysis by Michaelis-Menten analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50308960(2-(4-(9H-xanthene-9-carbonylcarbamothioyl)piperazi...)
Affinity DataKi:  1.98E+4nMAssay Description:Mixed-type inhibition of autotaxin-mediated FS3 hydrolysis by Michaelis-Menten analysis for enzyme-substrate complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed