BDBM50308522 9-[7',7'-Difluoro-7'-(diethylphosphono)heptyl]-9-deazaguanine::CHEMBL591019

SMILES CCOP(=O)(OCC)C(F)(F)CCCCCCc1c[nH]c2c1nc(N)[nH]c2=O

InChI Key InChIKey=YQNJUMKKHIZTJF-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50308522   

TargetPurine nucleoside phosphorylase(Bovine)
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308522(9-[7',7'-Difluoro-7'-(diethylphosphono)heptyl]-9-d...)
Affinity DataIC50: 42nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorganic pho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308522(9-[7',7'-Difluoro-7'-(diethylphosphono)heptyl]-9-d...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorgan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308522(9-[7',7'-Difluoro-7'-(diethylphosphono)heptyl]-9-d...)
Affinity DataKi:  13nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308522(9-[7',7'-Difluoro-7'-(diethylphosphono)heptyl]-9-d...)
Affinity DataKi:  21nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorg...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed