BDBM50308343 (Z)-5-(3,5-dibromo-4-methoxybenzylidene)thiazolidine-2,4-dione::CHEMBL591504::US10278929, Compound 8::US11337935, Compound 8

SMILES COc1c(Br)cc(\C=C2/SC(=O)NC2=O)cc1Br

InChI Key InChIKey=QXEKLTNOLUIGMQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50308343   

TargetTransthyretin(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM50308343((Z)-5-(3,5-dibromo-4-methoxybenzylidene)thiazolidi...)
Affinity DataIC50: 301nMAssay Description:The FP assay was then adapted for HTS and used to screen ~120,000 small molecule library for compounds that displaced probe 5 from the T4 binding of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2015
Entry Details
Go to US Patent

TargetInsulin receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50308343((Z)-5-(3,5-dibromo-4-methoxybenzylidene)thiazolidi...)
Affinity DataIC50: 6.53E+4nMAssay Description:Inhibition of IR by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50308343((Z)-5-(3,5-dibromo-4-methoxybenzylidene)thiazolidi...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of IGF1R by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTransthyretin(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM50308343((Z)-5-(3,5-dibromo-4-methoxybenzylidene)thiazolidi...)
Affinity DataIC50: 301nMAssay Description:The FP assay was then adapted for HTS and used to screen a 120,000 member small molecule library for compounds that displaced the FP probe from the T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
Go to US Patent

TargetTransthyretin(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM50308343((Z)-5-(3,5-dibromo-4-methoxybenzylidene)thiazolidi...)
Affinity DataIC50: 301nMAssay Description:Table 3: The FP assay was then adapted for HTS and used to screen 120,000 small molecule library for compounds that displaced probe 5 from the T4 bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
Go to US Patent