BDBM50308173 (3R)-1-[2-(1-Methylethyl)-3-(naphthalen-1-ylsulfonyl)-2Hindazol-5-yl]pyrrolidin-3-amine::CHEMBL591939

SMILES CC(C)n1nc2ccc(cc2c1S(=O)(=O)c1cccc2ccccc12)N1CC[C@@H](N)C1

InChI Key InChIKey=ZJUNSPZQENPTOE-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50308173   

Target5-hydroxytryptamine receptor 6(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308173((3R)-1-[2-(1-Methylethyl)-3-(naphthalen-1-ylsulfon...)
Affinity DataIC50: 380nMAssay Description:Antagonist activity at human cloned 5HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP formation by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308173((3R)-1-[2-(1-Methylethyl)-3-(naphthalen-1-ylsulfon...)
Affinity DataKi:  48.7nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308173((3R)-1-[2-(1-Methylethyl)-3-(naphthalen-1-ylsulfon...)
Affinity DataKi: >3.30E+3nMAssay Description:Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed