BDBM50308158 3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic Acid::3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid::CHEMBL590043

SMILES Cn1c(c(-c2cn(CCC(=O)Nc3ccc(cc3)-c3ccccc3)nn2)c2cc(C(O)=O)c(O)cc12)-c1ccccc1

InChI Key InChIKey=RATFAFAWIWHLMR-UHFFFAOYSA-N

Data  1 KI  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50308158   

TargetDual specificity protein phosphatase 3(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 5.00E+4nMpH: 7.0Assay Description:Inhibition of VHR expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of recombinant SHP2 (262 to 532 amino acids) (unknown origin) incubated for 1 hr using 10 uM DiFMUP by DiFMUP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant SHP2 (262 to 532 amino acids) (unknown origin) incubated for 1 hr using 20 uM DiFMUP by DiFMUP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of human 6his-tagged SHP2 (2 to 593 residues) expressed in Escherichia coli BL21 Star (DE3) cells preincubated with IRS1_pY1172(dPEG8)pY12...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of SHP2 expressed in Escherichia coli BL21 (DE3) cells using pNPP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDual specificity protein phosphatase CDC14A(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 5.00E+4nMpH: 7.0Assay Description:Inhibition of Cdc14A expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 3.11E+4nMpH: 7.0Assay Description:Inhibition of LMWPTP expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 5.50E+3nMpH: 7.0Assay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 5.00E+4nMpH: 7.0Assay Description:Inhibition of PTPalpha expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 5.00E+4nMpH: 7.0Assay Description:Inhibition of LAR expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase C(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 3.00E+4nMpH: 7.0Assay Description:Inhibition of CD45 expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 13(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 2.03E+4nMpH: 7.0Assay Description:Inhibition of FAP1 expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 2.50E+4nMpH: 7.0Assay Description:Inhibition of Lyp expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 7(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 5.00E+4nMpH: 7.0Assay Description:Inhibition of HePTP expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 1.43E+4nMpH: 7.0Assay Description:Inhibition of PTP1B expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 1.57E+4nMpH: 7.0Assay Description:Inhibition of SHP1 expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataKi:  5.20E+3nMAssay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis by Lin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed