BDBM50307935 (2R,3S)-N-(4-(3-Bromoanilino)quinazolin-6-yl)-3-(piperidin-1-ylmethyl)oxirane-2-carboxamide::CHEMBL598007

SMILES Brc1cccc(Nc2ncnc3ccc(NC(=O)[C@@H]4O[C@H]4CN4CCCCC4)cc23)c1

InChI Key InChIKey=KGIFCCDXPXCPKK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50307935   

TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM50307935((2R,3S)-N-(4-(3-Bromoanilino)quinazolin-6-yl)-3-(p...)
Affinity DataIC50: 1.24nMAssay Description:Inhibition of human recombinant EGFR expressed in insect cells by time-resolved fluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM50307935((2R,3S)-N-(4-(3-Bromoanilino)quinazolin-6-yl)-3-(p...)
Affinity DataIC50: 44nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cells after 8 hrs by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM50307935((2R,3S)-N-(4-(3-Bromoanilino)quinazolin-6-yl)-3-(p...)
Affinity DataIC50: 7nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cells after 1 hr by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50307935((2R,3S)-N-(4-(3-Bromoanilino)quinazolin-6-yl)-3-(p...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of chicken c-SrcMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed