BDBM50307876 (S)-1-((R)-2-amino-2-cyclohexylacetyl)-N-(4-carbamimidoylbenzyl)pyrrolidine-2-carboxamide dihydrochloride::CHEMBL598849::US11584714, Compound 1027::US12195427, Compound 1027

SMILES N[C@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N

InChI Key InChIKey=RMYIJADBJGXIMY-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50307876   

TargetProthrombin(Human)
The State University of New York

Curated by ChEMBL
LigandPNGBDBM50307876((S)-1-((R)-2-amino-2-cyclohexylacetyl)-N-(4-carbam...)
Affinity DataKi:  10nMAssay Description:Inhibition of human alpha-thrombin using tPa (CH3SO2-D-Cha-Gly-Arg-pNA.AcOH) as chromogenic substrate by kinetic photometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2016
Entry Details Article
PubMed
TargetProthrombin(Human)
The State University of New York

Curated by ChEMBL
LigandPNGBDBM50307876((S)-1-((R)-2-amino-2-cyclohexylacetyl)-N-(4-carbam...)
Affinity DataKi:  23nMAssay Description:Binding affinity to human thrombin by standard kinetic photometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMannan-binding lectin serine protease 2(Human)
Omeros

US Patent
LigandPNGBDBM50307876((S)-1-((R)-2-amino-2-cyclohexylacetyl)-N-(4-carbam...)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetProthrombin(Human)
The State University of New York

Curated by ChEMBL
LigandPNGBDBM50307876((S)-1-((R)-2-amino-2-cyclohexylacetyl)-N-(4-carbam...)
Affinity DataKi: <500nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetMannan-binding lectin serine protease 2(Human)
Omeros

US Patent
LigandPNGBDBM50307876((S)-1-((R)-2-amino-2-cyclohexylacetyl)-N-(4-carbam...)
Affinity DataKi: <500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetProthrombin(Human)
The State University of New York

Curated by ChEMBL
LigandPNGBDBM50307876((S)-1-((R)-2-amino-2-cyclohexylacetyl)-N-(4-carbam...)
Affinity DataKi: <500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent