BDBM50306432 CHEMBL601210::N-(adamantan-2-yl)-7-bromo-3-[(methanesulfonylcarbamoyl)methyl]-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxamide

SMILES CS(=O)(=O)NC(=O)CC1CC2(CCN(CC2)C(=O)NC2C3CC4CC(C3)CC2C4)c2c1cccc2Br

InChI Key InChIKey=AJHBTWPEUQMWQP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50306432   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306432(N-(adamantan-2-yl)-7-bromo-3-[(methanesulfonylcarb...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306432(N-(adamantan-2-yl)-7-bromo-3-[(methanesulfonylcarb...)
Affinity DataIC50: 22.3nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytes assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306432(N-(adamantan-2-yl)-7-bromo-3-[(methanesulfonylcarb...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed