BDBM50306110 CHEMBL607314::N-(2-hydroxy-2-phenylethyl)-6-(4-oxospiro[chroman-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide

SMILES OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)CC(=O)c1ccccc1O2)c1ccccc1

InChI Key InChIKey=OPPYXCWIDMCXMM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50306110   

TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306110(N-(2-hydroxy-2-phenylethyl)-6-(4-oxospiro[chroman-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of SCD1 in human 293A cells assessed as conversion of [14C]stearate to [14C]oleate after 60 mins in presence of S9 microsomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-CoA desaturase 1(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306110(N-(2-hydroxy-2-phenylethyl)-6-(4-oxospiro[chroman-...)
Affinity DataIC50: 250nMAssay Description:Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306110(N-(2-hydroxy-2-phenylethyl)-6-(4-oxospiro[chroman-...)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of human SCD1 expressed in human 293A cells assessed as conversion of [14C]stearate to [14C]oleateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306110(N-(2-hydroxy-2-phenylethyl)-6-(4-oxospiro[chroman-...)
Affinity DataIC50: 250nMAssay Description:Inhibition of human liver microsome SCD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcyl-CoA desaturase 1(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50306110(N-(2-hydroxy-2-phenylethyl)-6-(4-oxospiro[chroman-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of mouse liver microsome SCD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed