BDBM50305882 (S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)pyridin-3-yloxy)-3-(1H-indol-3-yl)propan-2-amine::CHEMBL603197

SMILES Cc1[nH]nc2cnc(nc12)-c1cc(OC[C@@H](N)Cc2c[nH]c3ccccc23)cnc1-c1ccoc1

InChI Key InChIKey=ZUFPYCGWUXYDBH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50305882   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305882((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305882((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305882((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of AKT3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305882((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50: 670nMAssay Description:Inhibition of GSK3-beta phosphorylation in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305882((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed