BDBM50305548 1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)-3-(pyridin-3-yl)urea::CHEMBL590105

SMILES FC(F)(F)Cn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)C1=CCOCC1

InChI Key InChIKey=DFZZGJMXAGYQAS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50305548   

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305548(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)-1-(2,2,2-trifl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50305548(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)-1-(2,2,2-trifl...)
Affinity DataIC50: 66nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305548(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)-1-(2,2,2-trifl...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed