BDBM50304943 CHEMBL590374::N-(2-hydroxy-2-phenylethyl)-6-(4-(2-(trifluoromethyl)benzoyl)piperidin-1-yl)pyridazine-3-carboxamideydroxy-2-phenylethyl)-6-(4-(3-(trifluoromethyl)benzoyl)piperidin-1-yl)pyridazine-3-carboxamide

SMILES OC(CNC(=O)c1ccc(nn1)N1CCC(CC1)C(=O)c1ccccc1C(F)(F)F)c1ccccc1

InChI Key InChIKey=WBULXKBWHYGHMK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50304943   

TargetAcyl-CoA desaturase 1(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304943(N-(2-hydroxy-2-phenylethyl)-6-(4-(2-(trifluorometh...)
Affinity DataIC50: 2nMAssay Description:Inhibition of Scd1 in mouse liver microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304943(N-(2-hydroxy-2-phenylethyl)-6-(4-(2-(trifluorometh...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Scd1 in human HEK293A cell microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304943(N-(2-hydroxy-2-phenylethyl)-6-(4-(2-(trifluorometh...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human Scd1 expressed in HEK293A cells assessed as conversion of [14C]stearate to [14C]oleate pretreated for 30 mins measured after 4 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed