BDBM50304193 CHEMBL593221::N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-6'-methoxy-7'-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4'-amine

SMILES COc1cc(ccc1Nc1ncnc2cc(OCCCN3CCN(C)CC3)c(OC)cc12)-c1nc2ccccc2s1

InChI Key InChIKey=DCKMTGBFLNPJPS-UHFFFAOYSA-N

Data  8 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50304193   

TargetAurora kinase B(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304193(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-6'-...)
Affinity DataIC50: 90nMAssay Description:Inhibition of Aurora-B by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50304193(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-6'-...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of VEGFR3 by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304193(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-6'-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of EGFR in human HCT116 cells by cellular phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiopoietin-1 receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304193(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-6'-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of TIE2 in human HCT116 cells by cellular phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50304193(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-6'-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of VEGFR3 in human HCT116 cells by cellular phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304193(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-6'-...)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of Aurora-B in human HCT116 cells by cellular proliferation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase A(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304193(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-6'-...)
Affinity DataIC50: 65nMAssay Description:Inhibition of Aurora-A by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50304193(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-6'-...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of VEGFR2 by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiopoietin-1 receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304193(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-6'-...)
Affinity DataIC50: 330nMAssay Description:Inhibition of TIE2 by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50304193(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-6'-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERBB2 by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50304193(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-6'-...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of PDGFRbeta by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304193(N-[4-(Benzo[d]thiazol-2''-yl)-2-hydroxyphenyl]-6'-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type EGF-R by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed