BDBM50303436 9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-9H-purine-2-carbonitrile::CHEMBL578159

SMILES FC(F)Cn1cnc2c(Nc3cc(F)cc(F)c3)nc(nc12)C#N

InChI Key InChIKey=VMJFQUMKCMNFSX-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50303436   

TargetCruzipain(Trypanosoma cruzi)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of Trypanosoma cruzi cruzain after 15 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin G(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 1.48E+5nMAssay Description:Inhibition of human Cathepsin GMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetChymase(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 8.91E+4nMAssay Description:Inhibition of human ChymaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeutrophil elastase(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 8.51E+4nMAssay Description:Inhibition of human ElastaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKallikrein-4(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 9.77E+3nMAssay Description:Inhibition of human Kallikrein 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-1(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 1.62E+4nMAssay Description:Inhibition of human Caspase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 1(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 6.92E+3nMAssay Description:Inhibition of human Cathepsin CMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin Z(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of human Cathepsin X/ZMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-14(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 4.27E+5nMAssay Description:Inhibition of human MMP14More data for this Ligand-Target Pair
In DepthDetails Article
PubMed