BDBM50298800 (+/-)-5-(3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-ynyl)-6-methylpyrimidine-2,4-diamine::Biphenyl antifolate, 3::CHEMBL584391::US8853228, 141

SMILES COc1cc(cc(c1)-c1ccc(C)cc1)C(C)C#Cc1c(C)nc(N)nc1N

InChI Key InChIKey=QVXYJVHNRPNRJL-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50298800   

TargetDihydrofolate reductase(Yeast)
University of Connecticut

LigandPNGBDBM50298800(CHEMBL584391 | Biphenyl antifolate, 3 | US8853228,...)
Affinity DataIC50: 0.610nMAssay Description:Enzyme activity assay were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over 5 min.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2011
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Connecticut

LigandPNGBDBM50298800(CHEMBL584391 | Biphenyl antifolate, 3 | US8853228,...)
Affinity DataIC50: 1.40E+3nMAssay Description:Enzyme activity assay were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over 5 min.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2011
Entry Details Article
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

US Patent
LigandPNGBDBM50298800(CHEMBL584391 | Biphenyl antifolate, 3 | US8853228,...)
Affinity DataIC50: 410nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
Go to US Patent

TargetDihydrofolate reductase(Streptococcus pyogenes (Firmicutes))
University of Connecticut

US Patent
LigandPNGBDBM50298800(CHEMBL584391 | Biphenyl antifolate, 3 | US8853228,...)
Affinity DataIC50: 350nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
Go to US Patent

TargetDihydrofolate reductase(Human)
University of Connecticut

LigandPNGBDBM50298800(CHEMBL584391 | Biphenyl antifolate, 3 | US8853228,...)
Affinity DataIC50: 1.40E+3nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
Go to US Patent

TargetDihydrofolate reductase(Yeast)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298800(CHEMBL584391 | Biphenyl antifolate, 3 | US8853228,...)
Affinity DataIC50: 22nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Connecticut

LigandPNGBDBM50298800(CHEMBL584391 | Biphenyl antifolate, 3 | US8853228,...)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of human DHFR assessed as rate of NADPH consumption using dihydrofolate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Connecticut

LigandPNGBDBM50298800(CHEMBL584391 | Biphenyl antifolate, 3 | US8853228,...)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Yeast)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298800(CHEMBL584391 | Biphenyl antifolate, 3 | US8853228,...)
Affinity DataIC50: 22nMAssay Description:Inhibition of Candida albicans DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed