BDBM50295760 1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-1H-pyrrolo[3,2-b]pyridin-6-amine::CHEMBL558306

SMILES Nc1cnc2ccn(c2c1)S(=O)(=O)c1c(Cl)nc2sccn12

InChI Key InChIKey=FASSZBVWSHEOJB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50295760   

TargetHepatocyte growth factor receptor(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50295760(1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-1H-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50295760(1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-1H-...)
Affinity DataIC50: 490nMAssay Description:Inhibition of c-Met phosphorylation in human MKN45 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50295760(1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-1H-...)
Affinity DataIC50: 580nMAssay Description:Inhibition of c-Met phosphorylation in human A549 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50295760(1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-1H-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed