BDBM50294542 1-Methoxy-3-methyl-10-(4-methyl-piperazin-1-yl)-5-phenethyl-5,6,7,12-tetrahydro-2,5,12-triaza-dibenzo[a,e]azulene::CHEMBL551570

SMILES COc1nc(C)cc2N(CCc3ccccc3)CCc3c([nH]c4cc(ccc34)N3CCN(C)CC3)-c12

InChI Key InChIKey=AAWMAJBBHSVQCG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50294542   

TargetInsulin receptor(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50294542(1-Methoxy-3-methyl-10-(4-methyl-piperazin-1-yl)-5-...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human recombinant IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50294542(1-Methoxy-3-methyl-10-(4-methyl-piperazin-1-yl)-5-...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of 6xHis-tagged human NPM-ALK expressed in insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50294542(1-Methoxy-3-methyl-10-(4-methyl-piperazin-1-yl)-5-...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of recombinant IGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50294542(1-Methoxy-3-methyl-10-(4-methyl-piperazin-1-yl)-5-...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of recombinant JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50294542(1-Methoxy-3-methyl-10-(4-methyl-piperazin-1-yl)-5-...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of recombinant METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed