BDBM50292912 17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy-6beta-[(2'-naphthalyl)acetamido]morphinan::CHEMBL493846

SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)NC(=O)c1ccc2ccccc2c1

InChI Key InChIKey=XZQMGGFIVXLGME-UHFFFAOYSA-N

Data  4 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50292912   

TargetMu-type opioid receptor(Human)
Alkermes

Curated by ChEMBL
LigandPNGBDBM50292912(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human mu-opioid receptor expressed in HEK293 cells coexpressing delta6-Galphaqi4-myr assessed as induction of intracellular calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2019
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Alkermes

Curated by ChEMBL
LigandPNGBDBM50292912(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human mu-opioid receptor expressed in HEK293 cell membranes after 1 hr by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2019
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Alkermes

Curated by ChEMBL
LigandPNGBDBM50292912(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  0.00130nMAssay Description:Displacement of [3H]-DAMGO from human HA-tagged mu-opioid receptor expressed in HEK293 cells after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2019
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292912(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]NTI from monocloned delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Alkermes

Curated by ChEMBL
LigandPNGBDBM50292912(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  56nMAssay Description:Activity at monocloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50292912(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  65nMAssay Description:Displacement of [3H]norBNI from monocloned kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed