BDBM50292568 CHEMBL4173696

SMILES C\C=C\c1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(OCCCN4CCOCC4)cc23)cc1

InChI Key InChIKey=BAILKEZVTQZRCF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50292568   

TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292568(CHEMBL4173696)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human N-terminal His-tagged EGFR (1 to 645 residues) expressed in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292568(CHEMBL4173696)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin) using ULight-poly GT as substrate preincubated for 30 mins followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292568(CHEMBL4173696)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) preincubated for 10 mins followed by TK substrate-botion addition measured after 1 hr by spectrophot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292568(CHEMBL4173696)
Affinity DataIC50: 236nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using ULight-poly GT as substrate preincubated for 120 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292568(CHEMBL4173696)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human C-terminal His-tagged EGFR (1 to 645 residues) expressed in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed