BDBM50290835 (3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine::CHEMBL100714::CHEMBL544833

SMILES COc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1OC

InChI Key InChIKey=CCHZXKUIBPNVKD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50290835   

TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50290835(CHEMBL100714 | CHEMBL544833 | (3,4-Dimethoxy-pheny...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of epidermal growth factor receptor (EGF-R)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

LigandPNGBDBM50290835(CHEMBL100714 | CHEMBL544833 | (3,4-Dimethoxy-pheny...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50290835(CHEMBL100714 | CHEMBL544833 | (3,4-Dimethoxy-pheny...)
Affinity DataIC50: 350nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation, 0.05-0.10More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article

TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50290835(CHEMBL100714 | CHEMBL544833 | (3,4-Dimethoxy-pheny...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article

TargetDual specificity protein kinase CLK1(Human)
Rajiv Gandhi Proudyogiki Vishwavidyalaya

Curated by ChEMBL
LigandPNGBDBM50290835(CHEMBL100714 | CHEMBL544833 | (3,4-Dimethoxy-pheny...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human recombinant GST-fused CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Rajiv Gandhi Proudyogiki Vishwavidyalaya

Curated by ChEMBL
LigandPNGBDBM50290835(CHEMBL100714 | CHEMBL544833 | (3,4-Dimethoxy-pheny...)
Affinity DataIC50: 1.00E+4nMAssay Description:inhibition of human recombinant CDK5/p25 using histone H1 as substrate by scintillation counting in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
LigandPNGBDBM50290835(CHEMBL100714 | CHEMBL544833 | (3,4-Dimethoxy-pheny...)
Affinity DataIC50: 7.38E+3nMAssay Description:Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation treated 30 mins before Hoechst 33342 addition measured up to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandPNGBDBM50290835(CHEMBL100714 | CHEMBL544833 | (3,4-Dimethoxy-pheny...)
Affinity DataIC50: 3.79E+3nMAssay Description:Inhibition of human BCRP expressed in MDCK2 cells assessed as pheophorbide A accumulation treated 30 mins before pheophorbide A addition measured up ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed