BDBM50290145 CHEMBL2018584

SMILES COc1cccc(OC)c1C(=O)NCCNc1nc2cc(C)cc(C)c2cc1C#N

InChI Key InChIKey=VWRLBIFOCRNTBJ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50290145   

TargetCystic fibrosis transmembrane conductance regulator(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50290145(CHEMBL2018584)
Affinity DataEC50:  3.72E+3nMAssay Description:Corrector activity at CFTR F508-del mutant (unknown origin) expressed in human CFBE41o cells harboring HS-YFP preincubated for 24 hrs followed by for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2020
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50290145(CHEMBL2018584)
Affinity DataEC50:  3.70E+3nMAssay Description:Activity at human CFTR delta F508 mutant expressed in forskolin-stimulated FRT cells assessed as increase in iodine influx measured as decrease in YF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed