BDBM50287072 CHEMBL4159112::US10759787, Example 12::US11059811, Example 12

SMILES CCN(C1CCOCC1)c1cc2oc(CN3CCN(C)CC3)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1CC

InChI Key InChIKey=YFLOKCLJSQKUIO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50287072   

LigandPNGBDBM50287072(CHEMBL4159112 | US10759787, Example 12 | US1105981...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM50287072(CHEMBL4159112 | US10759787, Example 12 | US1105981...)
Affinity DataIC50: 10nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM50287072(CHEMBL4159112 | US10759787, Example 12 | US1105981...)
Affinity DataIC50: 10nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent