BDBM50286737 CHEMBL4160865

SMILES Cc1ccc2nc([C@H](CC3CCNCC3)N3C(=O)CN(C3=O)c3ccc(Oc4ccccc4)cc3)n(C)c2c1

InChI Key InChIKey=OSIAUSSYLUETML-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50286737   

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50286737(CHEMBL4160865)
Affinity DataIC50: 6.40E+4nMAssay Description:Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50286737(CHEMBL4160865)
Affinity DataIC50: 4.51E+3nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details Article
PubMed