BDBM50286245 CHEMBL4163070::US11981669, Comparative Example 1

SMILES OC(=O)CNC(=O)c1nc(Cl)c2cc(Oc3ccccc3)ccc2c1O

InChI Key InChIKey=YXAUESXRNXRXCG-UHFFFAOYSA-N

Data  5 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50286245   

TargetEgl nine homolog 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50286245(CHEMBL4163070 | US11981669, Comparative Example 1)
Affinity DataEC50:  1.90E+4nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEgl nine homolog 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50286245(CHEMBL4163070 | US11981669, Comparative Example 1)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human HIF-PHD2 assessed as reduction in HIF1-alpha binding to VBC complex using biotin-labeled HIF1-alpha peptide as substrate preincub...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50286245(CHEMBL4163070 | US11981669, Comparative Example 1)
Affinity DataEC50:  30nMAssay Description:Agonist activity at wild type human TR alpha LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of N-terminal biotinylated coactivato...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThyroid hormone receptor beta(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50286245(CHEMBL4163070 | US11981669, Comparative Example 1)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human TR beta LBD (202 to 461 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of N-terminal biotin...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEgl nine homolog 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50286245(CHEMBL4163070 | US11981669, Comparative Example 1)
Affinity DataIC50: 50nMAssay Description:Inhibition of PHD2 (unknown origin) incubated for 15 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProlyl hydroxylase EGLN2(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co.

US Patent
LigandPNGBDBM50286245(CHEMBL4163070 | US11981669, Comparative Example 1)
Affinity DataIC50: 273nMAssay Description:VHL/elongin B/elongin C were constructed, expressed and purified, and VHL was labeled. PHD1, PHD2 and PHD3 were constructed, expressed and purified. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEgl nine homolog 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50286245(CHEMBL4163070 | US11981669, Comparative Example 1)
Affinity DataIC50: 770nMAssay Description:VHL/elongin B/elongin C were constructed, expressed and purified, and VHL was labeled. PHD1, PHD2 and PHD3 were constructed, expressed and purified. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProlyl hydroxylase EGLN3(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co.

US Patent
LigandPNGBDBM50286245(CHEMBL4163070 | US11981669, Comparative Example 1)
Affinity DataIC50: 561nMAssay Description:VHL/elongin B/elongin C were constructed, expressed and purified, and VHL was labeled. PHD1, PHD2 and PHD3 were constructed, expressed and purified. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent