BDBM50284769 (S)-2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{(S)-2-cyclopropyl-2-[((2R,6S)-2,6-dimethyl-piperidine-1-carbonyl)-amino]-acetylamino}-propionylamino)-hexanoic acid::CHEMBL284250

SMILES CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(O)=O

InChI Key InChIKey=XDNAXXIOBHFZDQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50284769   

TargetEndothelin receptor type B(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50284769((S)-2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{(S)-2-cycl...)
Affinity DataIC50: 0.810nMAssay Description:Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin B receptor in porcine cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetEndothelin-1 receptor(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50284769((S)-2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{(S)-2-cycl...)
Affinity DataIC50: 3.80nMAssay Description:Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.More data for this Ligand-Target Pair
In DepthDetails Article

TargetEndothelin receptor type B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50284769((S)-2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{(S)-2-cycl...)
Affinity DataIC50: 0.800nMAssay Description:Functional inhibition of ET-1 induced [Ca2+] increase in human Girardi heart (hGH) cells, which express Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails Article

TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50284769((S)-2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{(S)-2-cycl...)
Affinity DataIC50: 16nMAssay Description:Functional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails Article