BDBM50283443 CHEMBL4170030

SMILES Cn1cc(cc(-c2cccc(c2)C#N)c1=O)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cn1

InChI Key InChIKey=BFEHRVHTPYQIGG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50283443   

TargetEukaryotic initiation factor 4A-I(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50283443(CHEMBL4170030)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2020
Entry Details Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50283443(CHEMBL4170030)
Affinity DataIC50: 100nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2020
Entry Details Article
PubMed
TargetEukaryotic initiation factor 4A-II(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50283443(CHEMBL4170030)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A2 RNA dependent ATPase activity using single stranded poly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2020
Entry Details Article
PubMed
TargetU5 small nuclear ribonucleoprotein 200 kDa helicase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50283443(CHEMBL4170030)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal full length His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2020
Entry Details Article
PubMed
TargetATP-dependent RNA helicase DHX29(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50283443(CHEMBL4170030)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal full length FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2020
Entry Details Article
PubMed