BDBM50281170 CHEMBL4165923::US20240034730, Compound 2

SMILES Cc1cccc2c(C(=O)Nc3c(F)c(F)c(-c4ccccc4)c(F)c3F)c(O)nn12

InChI Key InChIKey=QHNZRENACMJYNG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50281170   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50281170(CHEMBL4165923 | US20240034730, Compound 2)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human DHODH (31 to 395 residues) expressed in Escherichia coli BL21(DE3) assessed as inhibition of DC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50281170(CHEMBL4165923 | US20240034730, Compound 2)
Affinity DataIC50: 4.30nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50281170(CHEMBL4165923 | US20240034730, Compound 2)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50281170(CHEMBL4165923 | US20240034730, Compound 2)
Affinity DataIC50: 4.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
Go to US Patent