BDBM50280368 CHEMBL4176971

SMILES COc1ccc(cc1OC)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1

InChI Key InChIKey=YCDOKDADFOBKIL-UHFFFAOYSA-N

Data  15 IC50  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50280368   

TargetMetabotropic glutamate receptor 3(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mGlu3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 710nMAssay Description:Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 710nMAssay Description:Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 794nMAssay Description:Negative allosteric modulation of rat mGlu7 in HEK cells expressing Galpha15 assessed as inhibition of L-AP4-induced response measured by calcium mob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 759nMAssay Description:Negative allosteric modulation of rat mGlu7 in HEK cells expressing Galpha15 assessed as inhibition of L-AP4-induced response measured by calcium mob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 760nMAssay Description:Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring Ga15 assessed as reduction in L-AP4-induced calcium flux preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 759nMAssay Description:Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring Ga15 assessed as reduction in L-AP4-induced calcium flux preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mGlu1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at rat mGlu8 expressed in HEK cells co-expressing Galpha15 assessed as reduction in L-AP4-induced intracellular calcium flux pret...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mGlu2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat mGlu8 expressed in HEK cells co-expressing Galpha15 measured after 142 secs by Fluo-4 AM dye based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mGlu5 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mGlu6 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human mGlu4 expressed in CHO cells co-expressing Gqi5 assessed as reduction in L-AP4-induced intracellular calcium flux pretre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 759nMAssay Description:Negative allosteric modulation of rat mGlu7 expressed in HEK cells co-expressing Galpha15 assessed as reduction in L-AP4-induced intracellular calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 760nMAssay Description:Negative allosteric modulation of rat mGlu7 expressed in HEK cells co-expressing Galpha15 assessed as reduction in L-AP4-induced intracellular calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human mGlu4 expressed in CHO cells co-expressing Gqi5 after 142 secs by Fluo-4AM dye based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu5 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu6 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed