BDBM50279162 (Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic Acid Isopropylamide::CHEMBL524647

SMILES CC(C)NC(=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1

InChI Key InChIKey=AHANRVPTDMPJAT-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50279162   

TargetTGF-beta receptor type-1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279162((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Affinity DataIC50: 318nMAssay Description:Inhibition of TGFbeta receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279162((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Affinity DataEC50:  708nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279162((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of human VEGFR2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed