BDBM50279050 CHEMBL4169347

SMILES CS(=O)(=O)c1ccc2n(C(=O)c3ccc(Cl)cc3)c3CCCC(=O)c3c2c1

InChI Key InChIKey=MITGKKFYIJJQGL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50279050   

TargetProstaglandin G/H synthase 1(Human)
Damanhour University

Curated by ChEMBL
LigandPNGBDBM50279050(CHEMBL4169347)
Affinity DataIC50: 1.04E+5nMAssay Description:Inhibition of human COX-1 using [14C]-arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Human)
Damanhour University

Curated by ChEMBL
LigandPNGBDBM50279050(CHEMBL4169347)
Affinity DataIC50: 23nMAssay Description:Inhibition of human kidney microsomal COX assessed as PGE2 level using arachidonic acid as substrate preincubated for 5 to 15 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Damanhour University

Curated by ChEMBL
LigandPNGBDBM50279050(CHEMBL4169347)
Affinity DataIC50: 48nMAssay Description:Inhibition of rat kidney microsomal COX assessed as PGE2 level using arachidonic acid as substrate preincubated for 5 to 15 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Damanhour University

Curated by ChEMBL
LigandPNGBDBM50279050(CHEMBL4169347)
Affinity DataIC50: 230nMAssay Description:Inhibition of human COX-2 using [14C]-arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details Article
PubMed