BDBM50279044 (Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic Acid Amide::CHEMBL497949

SMILES NC(=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1

InChI Key InChIKey=QMPQJWQHTDPWNU-UHFFFAOYSA-N

Data  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50279044   

TargetTGF-beta receptor type-1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279044((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279044((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279044((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Affinity DataIC50: 369nMAssay Description:Inhibition of TGFbeta receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279044((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Affinity DataIC50: 763nMAssay Description:Inhibition of human VEGFR2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279044((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human IGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279044((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human InsRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279044((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279044((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279044((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279044((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Plk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed