BDBM50276756 4,9-bis(3,5-dihydroxyphenoxy)benzofuro[3,2-a]dibenzo[b,e][1,4]dioxine-1,3,6,10,12-pentaol::CHEMBL510508::Phlorofucofuroeckol-A::US10106521, Compound Phlorofucofuroeckol A::phlorofucofuroeckol A

SMILES Oc1cc(O)cc(Oc2c(O)cc(O)c3Oc4c(Oc23)c(O)cc2oc3c(Oc5cc(O)cc(O)c5)c(O)cc(O)c3c42)c1

InChI Key InChIKey=SLWPBUMYPRVYIJ-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50276756   

TargetBeta-secretase 1(Human)
Pukyong National University

Curated by ChEMBL
LigandPNGBDBM50276756(phlorofucofuroeckol A | 4,9-bis(3,5-dihydroxypheno...)
Affinity DataIC50: 2.13E+3nMAssay Description:Inhibition of human recombinant BACE1 after 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Phloronol

US Patent
LigandPNGBDBM50276756(phlorofucofuroeckol A | 4,9-bis(3,5-dihydroxypheno...)
Affinity DataIC50: 9.41E+4nMpH: 7.4 T: 2°CAssay Description:Enzyme activities were determined at room temperature. Ultraviolet absorbance was measured spectrophotometrically by a modification of a previously d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
Go to US Patent

TargetCholinesterase(Human)
Phloronol

US Patent
LigandPNGBDBM50276756(phlorofucofuroeckol A | 4,9-bis(3,5-dihydroxypheno...)
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Enzyme activities were determined at room temperature. Ultraviolet absorbance was measured spectrophotometrically by a modification of a previously d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
Go to US Patent

TargetReplicase polyprotein 1ab(SARS-CoV)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50276756(phlorofucofuroeckol A | 4,9-bis(3,5-dihydroxypheno...)
Affinity DataIC50: 1.75E+5nMAssay Description:Inhibition of SARS coronavirus 3C-like protease cis-cleavage activity transfected in african green monkey Vero cells using SAVLQSGFRK as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50276756(phlorofucofuroeckol A | 4,9-bis(3,5-dihydroxypheno...)
Affinity DataIC50: 1.67E+4nMAssay Description:Inhibition of C-terminal His6-tagged recombinant SARS coronavirus 3C-like protease trans-cleavage activity expressed in Escherichia coli BL21 (DE3) u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pukyong National University

Curated by ChEMBL
LigandPNGBDBM50276756(phlorofucofuroeckol A | 4,9-bis(3,5-dihydroxypheno...)
Affinity DataKi:  1.30E+3nMAssay Description:Noncompetitive inhibition of human recombinant BACE1 after 60 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50276756(phlorofucofuroeckol A | 4,9-bis(3,5-dihydroxypheno...)
Affinity DataKi:  1.06E+4nMAssay Description:Competitive inhibition of C-terminal His6-tagged recombinant SARS coronavirus 3C-like protease trans-cleavage activity expressed in Escherichia coli ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed