BDBM50273458 (5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one::(S)-2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydroxypropan-2-yl)-5-methylthiazol-4(5H)-one::CHEMBL455907

SMILES C[C@H](NC1=NC(=O)[C@@](C)(S1)C(C)(C)O)c1ccc(F)cc1

InChI Key InChIKey=HYVZYASDRIAOPU-UHFFFAOYSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50273458   

LigandPNGBDBM50273458((S)-2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydr...)
Affinity DataIC50: 140nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50273458((S)-2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydr...)
Affinity DataIC50: 340nMAssay Description:Inhibition of rat 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50273458((S)-2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydr...)
Affinity DataIC50: 45nMAssay Description:Inhibition of dog 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50273458((S)-2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydr...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50273458((S)-2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydr...)
Affinity DataKi:  12nMAssay Description:Inhibition of dog recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50273458((S)-2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydr...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50273458((S)-2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydr...)
Affinity DataKi:  100nMAssay Description:Inhibition of mouse recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50273458((S)-2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydr...)
Affinity DataKi:  300nMAssay Description:Inhibition of rat recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed