BDBM50273009 CHEMBL4129809

SMILES N[C@@H]1CCCN(C1)[C@@H]1Cc2ccccc2[C@H]1Oc1ccc(cc1Cl)C#N

InChI Key InChIKey=RLKRLNQEXBPQGQ-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50273009   

TargetShort transient receptor potential channel 6(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50273009(CHEMBL4129809)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of human TRPC6 expressed in HEK293 cells assessed as decrease in intracellular calcium level after 24 hrs by Fluo-4 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetShort transient receptor potential channel 7(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50273009(CHEMBL4129809)
Affinity DataIC50: 226nMAssay Description:Inhibition of human TRPC7 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetShort transient receptor potential channel 6(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50273009(CHEMBL4129809)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in TRPC6-induced current by Whole-cell patch-clampMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetShort transient receptor potential channel 4(Mouse)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50273009(CHEMBL4129809)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mouse TRPC4 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetShort transient receptor potential channel 6(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50273009(CHEMBL4129809)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetShort transient receptor potential channel 5(Mouse)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50273009(CHEMBL4129809)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mouse TRPC5 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetShort transient receptor potential channel 3(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50273009(CHEMBL4129809)
Affinity DataIC50: 282nMAssay Description:Inhibition of human TRPC3 expressed in CHO cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed