BDBM50272571 CHEMBL4127641
SMILES COc1ccc2c(NC(C)Cc3cc(C)[nH]n3)ncnc2c1OC
InChI Key InChIKey=JTROLECZHRVLFM-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50272571
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Human)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant C-terminal FLAG tagged human PDE1C expressed in HEK293 cells using 3',5'-[3H]cAMP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibition of recombinant human PDE3A expressed in HEK293 cells using 3',5'-[3H]cAMP as substrateMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Human)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant C-terminal FLAG tagged human PDE1C expressed in HEK293 cells using 3',5'-[3H]cGMP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 3.69E+5nMAssay Description:Inhibition of recombinant human PDE3A expressed in HEK293 cells using 3',5'-[3H]cGMP as substrateMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Human)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 118nMAssay Description:Inhibition of full length recombinant human PDE1A using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of full length recombinant human PDE1B1 using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Human)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 83nMAssay Description:Inhibition of full length recombinant human PDE1C using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.03E+4nMAssay Description:Inhibition of recombinant human PDE5A expressed in HEK293 cells using 3',5'-[3H]cGMP as substrateMore data for this Ligand-Target Pair